HAEMOPOIETIC STEM CELL TRANSPLANTATION FROM UNRELATED DONORS.
نویسندگان
چکیده
منابع مشابه
Unrelated donor haemopoietic stem-cell transplantation: ATG or not?
Chronic graft-versus-host disease (GVHD) is a multisystemic syndrome involving tissue inflammation and fibrosis that shares many clinical manifestations with autoimmune diseases such as systemic lupus erythematous or systemic sclerosis. Despite being associated with lower relapse rates, chronic GVHD is the main cause of late mortality after unrelated allogeneic haemopoietic stem-cell transplant...
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Transplantation of hematopoietic stem cells from human leukocyte antigen (HLA)-compatible unrelated volunteer donors have become feasible for more than 70% of patients without a family match. Chronic myeloid leukemia is the most common indication for unrelated donor marrow transplantation. The 5year survival for patients up the age of 50 years has improved to 75% with transplantation in the chr...
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Peripheral blood stem cell (PBSC) transplants from HLA-A, -B, and -DR compatible unrelated donors (n = 45) were compared with bone marrow (BM; BM group, n = 45). Eighteen patients received CD34-selected PBSC (CD34 group). The PBSCs contained more mononuclear cells, CD34(+), CD3(+), and CD56(+) cells compared with marrow (P <.001). Engraftment was achieved in all 45 patients in the BM group, in ...
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PURPOSE A fludarabine-based "nonmyeloablative" preparative regimen was investigated in 42 patients with hematological malignancies receiving hematopoietic stem cell grafts from unrelated volunteer donors. EXPERIMENTAL DESIGN Recipient conditioning consisted of fludarabine 30 mg/m(2) on days -6 to -2 and i.v. busulfan 3.3 mg/kg on days -6 to -5. Antithymocyte globuline was added at 2.5 mg/kg i...
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Killer immunoglobulin-like receptor (KIR) ligand incompatibility in the graft-versus-host direction was demonstrated to be associated with improved outcome in patients given haploidentical, T-cell-depleted hematopoietic stem cell transplants (HSCTs). The goal of this study was to evaluate whether that observation could be generalized for patients receiving unmanipulated HSCTs from unrelated don...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1999
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.1999.01326.x